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KMID : 0613820040140010141
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Journal of Life Science
2004 Volume.14 No. 1 p.141 ~ p.147
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Effect of Terminalia chebula Extract on Liver in Rat
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Park Jong-Ok
Lee In-Sub
Choi Jong-Won
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Abstract
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In this study, we investigated the effect of Terminalia Chebula (TC) water extract on liver in Rat. Treatment of TC water extract was orally administered 200, 300 mg/kg daily for one week and two weeks. The clinical parameters of serum, values of AST, ALT showed significantly higher than in normal group. Xanthine oxidase and aldehyde oxidase activities were significantly increased comparison with normal group. Microsomal enzymes, aminopyrine N-demethylase and aniline hydroxylase were not affected. Water extract of TC also increased hepatic malondialdehyde formation and reduced glutathione content. We also found that water extract of TC decreased activities of glutathione S-transferase and glutathione reductase but was not affected activities of γ-glutamylcysteine synthetase. Thus, it seems that the water extract of TC induced decrease of oxygen free radical scavenger, glutathione content by inhibition of glutathione reductase which may reform oxidized glutathione to reduced glutathione.
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KEYWORD
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Terminalia Chebula, xanthine oxidase, aldehyde oxidase, glutathione, γ-glutamylcysteine synthetase
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